2-amino benzimidazole derivatives and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S307400

Reexamination Certificate

active

07737167

ABSTRACT:
This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

REFERENCES:
patent: 2009/0131503 (2009-05-01), Annedi et al.
patent: WO-00/01676 (2000-01-01), None
patent: WO-00/69838 (2000-11-01), None
patent: WO-01/02406 (2001-01-01), None
patent: WO-03/094861 (2003-11-01), None
patent: WO-2004/035056 (2004-04-01), None
Parihar et al. Alzheimer's disease pathogenesis and therapeutic interventions, Journal of Clinical Neuroscience (2004) 11(5), 456-467.
Loscher et al. Drug Resistance in Brain Diseases and the Role of Drug Efflux Transporters, Nature Reviews, vol. 6, Aug. 2005, 591-602.
Strobek et al. Pharmacological characterization of small-conductance Ca2- activated K channels expressed in HEK293 cells, British Journal of Pharmacology (2000) 129, 991-999.
Claudia A. Sailer et al., Mol. Cell. Neurosci. 26 (2004) pp. 458-469.
J.-F Liegeois et al., Current Medicinal Chemistry, 2003, 10, pp. 625-647.

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