2-(Amino acid-thio)-1-carbapen-2-em-3-carboxylic acids and conge

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...

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Details

260239A, 2602452T, C07D48704, C07D20508, A61K 3140

Patent

active

043829490

ABSTRACT:
2-(Amino acid-thio)-1-carbapen-2-em-3-carboxylic acids and congeners having useful antibacterial activity are disclosed. The compounds are prepared in a reaction sequence starting with a 4-allylazetidinone.

REFERENCES:
patent: 4172144 (1979-10-01), Bouffard
"Introduction to Stereochemistry", Mislow (ed) pp. 94-97 (1965).
"Topics in Current Chemistry #48: Stereochemistry II, pp. 26-27 (1974).
Kropp, Paper #231, and Wildonger, paper #232 in 11th Int. Congress of Chemotherapy, ICAAC, 19th Interscience Conference on Antimicrobial Agents & Chemotherapy, Boston 1-5, 1979.

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