Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2005-05-31
2005-05-31
McKenzie, Thomas C. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C514S081000, C514S099000, C514S211100, C514S211110, C514S230500, C514S249000, C514S253010, C514S253110, C514S263200
Reexamination Certificate
active
06900315
ABSTRACT:
The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases caused by retroviral infection. More particularly, in preferred aspects, the present invention provides a method for the use of novel prodrug forms of 9-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl) guanine (d4G) for the prevention and treatment of both wild type and drug-resistant Human Immunodeficiency Virus (HIV), the causative pathogen of AIDS. Compounds according to the present invention are based upon the chemical formula:where X is OCH3, N3, NHCH3, N(CH3)2or an aminocyclopropyl group;R1is H or a C1to C20acyl or ether group, a phosphate, diphosphate, triphosphate or phosphodiester group; andR2is H or a C1to C20acyl or alkyl group.
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Anderson Karen S.
Chu Chung K.
Ray Adrian Staffin
Zhenjun Yang
Coleman Henry D.
McKenzie Thomas C.
Sapone William J.
Sudol R. Neil
University of Georgia Research Foundation Inc.
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