Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-10-31
1991-01-15
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544280, A61K 31505, C07D48700
Patent
active
049854330
ABSTRACT:
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is optionally substituted pyridinyl, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
REFERENCES:
patent: 4921858 (1990-05-01), Malone et al.
patent: 4923872 (1990-05-01), Kostlan et al.
M. I. Lim et al., J. Org. Chem. 44, 3826 (1979).
M. I. Lim et al., Tetrahedron Lett. 21, 1013 (1980).
M. I. Lim et al., Tetrahedron Lett. 22, 25 (1981).
M. I. Lim et al., J. Org. Chem. 48, 780 (1983).
Ealick Steve E.
Erion Mark D.
Guida Wayne C.
Montgomery John A.
Secrist, III John A.
BioCryst, Inc.
Shen Cecilia
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