2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544280, A61K 31505, C07D48700

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active

049854330

ABSTRACT:
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is optionally substituted pyridinyl, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.

REFERENCES:
patent: 4921858 (1990-05-01), Malone et al.
patent: 4923872 (1990-05-01), Kostlan et al.
M. I. Lim et al., J. Org. Chem. 44, 3826 (1979).
M. I. Lim et al., Tetrahedron Lett. 21, 1013 (1980).
M. I. Lim et al., Tetrahedron Lett. 22, 25 (1981).
M. I. Lim et al., J. Org. Chem. 48, 780 (1983).

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