Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1992-06-29
1994-05-17
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C07C10172
Patent
active
053129610
ABSTRACT:
The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula ##STR1## wherein Alk represents a straight or branched (C.sub.3 -C.sub.5)alkylene group, and R is hydrogen or (C.sub.1 -C.sub.4)alkyl, useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) ##STR2## wherein X represents hydrogen, halogen, (C.sub.1 -C.sub.4)alkyl, or trifluoromethyl which are useful as spasmolytics and anti-glaucoma agents.
The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the compounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.
REFERENCES:
patent: 4921998 (1990-05-01), Niewhoner et al.
patent: 4954504 (1990-09-01), Chen et al.
De Wied, Ed., European Journal of Pharmacology, 100, Nos. 3-4, 1984, pp. 309-319.
Wilson et al., Journal of Cardiovascular Pharmacology, 6, No. 6, Nov./Dec. 1984, pp. 1216-1221.
Manara et al., Fidia Research Foundation Symposium Series, 2, May 1989, pp. 131-147.
Forth et al., Ed., Pharmakologie und Toxikologie, 1983, 4th edition, pp. 94-95.
Wilson et al., Life Sciences, 35, No. 12, Sep. 1984, pp. 1301-1309.
Cecchi Roberto
Guzzi Umberto
Manara Luciano
Barts Samuel
Dees Jos,e G.
Elf Sanofi
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