Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-10-31
1991-04-16
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544280, A61K 31505, C07D48704
Patent
active
050082701
ABSTRACT:
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
REFERENCES:
patent: 4921858 (1990-05-01), Malone et al.
patent: 4923872 (1990-05-01), Kostlan et al.
Lim et al, J. Org. Chem., vol. 44, No. 22, 1979, pp. 3826-3829.
Lim et al, Tetrahedron Lett., vol. 21, pp. 1013-1016 (1980).
Lim et al, J. Org. Chem. 1983, 48, 780-788.
Ealick Steve E.
Erion Mark D.
Guida Wayne C.
Montgomery John A.
Secrist, III John A.
BioCryst, Inc.
Shen Cecilia
LandOfFree
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