Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-10-06
1991-11-26
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 26, C07H 19173
Patent
active
050683209
ABSTRACT:
This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and derivatives thereof. The compounds are useful as antivirals.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
Joachim Engels, Tetrahedron Letters, vol. 21, pp. 4339-4342, Synthesis of 2'-End Modified 2', 5'-Andenylate Trimers, 1980.
Bioorg Khim, 9, (1), pp. 52-59, (1983).
McCollum, Viral Hepatitis, pp. 327-350, Chapter 12, 1982, Second Edition.
Horwitz, et al., J. Org. Chem., 31, pp. 205-211, (1966), Nucleosides, IX, The Formation of 2', 3'-Unsaturated Pyrimidine Nucleosides via a Novel .beta.-Elimination Reaction.sup.1,2.
Krenitsky, et al., Biochemistry, 1981, 20, pp. 3615-3621, Purine Nucleoside Synthesis, and Efficient Method Employing Nucleoside Phosphorylases.
Davies, et al., Biochimica et Biophysica Acta, 564, (1979), pp. 448-455, The Interaction of 2,6,8-Triaminopurine with Poly (Uridylic Acid).
Mitsuya, et al., Proc. Natl. Acad. Sci., U.S.A., vol. 82, pp. 7096-7100, Oct. 1985, Medical Sciences, 3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of . . .
Synthetic communications 15(5), 401-409, (1985)--A Novel and Efficient Preparation of 2',3'-Dideoxynucleosides, Prisbe, et al.
Biochemical and Biophysical Research Communications, vol. 148, No. 3, pp. 1252-1258, 1987.
Antimicrobial Agents and Chemotherapy, vol. 31, No. 10, pp. 1613-1617, 1987.
Antimicrobial Agents and Chemotherapy, vol. 31, No. 9, pp. 1369-1374, 1987.
Molecular Pharmacology, 32, pp. 162-167, 1987.
Journal of Chromatography, 420, 1987, pp.1-12.
Biochemical Pharmacology, vol. 36, No. 14, pp. 2255-2262, 1987.
J. Med. Chem., 30, pp. 2131-2137, 1987.
Nucleic Acids Research 2(1), pp. 43-60, 1975.
Journal of the American Chemical Society, 98(25), pp. 8213-8217.
Biochemical Pharmacology, vol. 36, No. 11, pp. 1765-1768, 1987.
Proc. Natl. Acad. Sci., vol. 84, pp. 2469-2473, 1987.
Biochemistry, 19(1), pp. 102-107, 1980.
Biochimica et Biophysica Acta, 566(2), pp. 259-265, 1979.
Tetrahedron Letters vol. 21, pp. 4339-4342, 1980.
Biochemistry, vol. 25, No. 16, pp. 4473-4478, l986.
Journal of Cellular Physiology, 121(2), pp. 401-409, 1985.
Biochemical and Biophysical Researcht Communications, vol. 145, No. 1, 1987, pp. 277-283.
Biochemical and Biophysical Research Communications, vol. 145, No. 1, 1987, pp. 269-276.
Lohse, et al., European Journal of Pharmacology, 156, (1988), pp. 157-160, 2',3'-Dideoxy-N.sup.6 -cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.
Lohse, et al., Chemical Abstract--1989, vol. 110, p. 71, 18631f, 2',3'-Dideoxy-N.sup.6 -cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.
Burns Charlene L.
Koszalka George W.
Krenitsky Thomas A.
Rideout Janet L.
Brown Donald
Brown Johnnie R.
Burroughs Wellcome Co.
Crane L. Eric
Green Hannah O.
LandOfFree
2-amino-6-(cyclopropylamino)purine-9-.beta.-D-2',3'-dideo xyribo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-amino-6-(cyclopropylamino)purine-9-.beta.-D-2',3'-dideo xyribo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-amino-6-(cyclopropylamino)purine-9-.beta.-D-2',3'-dideo xyribo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2386499