Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-12-28
1995-12-26
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 514 19, 530328, 530329, 530330, 530331, 562426, 562556, A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
054788080
ABSTRACT:
A compound of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or aliphatic acyl, A is amino which may be protected, X is an amino acid sequence consisting of 1 to 10 amino acid residues which contain at least one amino acid residue having a water-solubility enhancing group, or a salt thereof has an activity of remarkably improving hematopoietic disorder and is useful as an immuno-stimulating agent or an agent for treating thrombocytopenia.
REFERENCES:
patent: 4666886 (1987-05-01), Baschang et al.
Metzger et al., Int. J. Peptide Protein Res., "Synthesis of N.sub..alpha. -Fmoc protected derivatives of S-(2,3-dihydroxyproply)-cysteine and their application in peptide synthesis", vol. 38, No. 6, pp. 545-554 (1991).
Chem. Pharm. Bull, "Synthesis of Optically Active Lipopeptide Analogs from the Outer Membrane of Escherichia Coli" Kurimura et al., 39 (10), pp. 2590-2596 (1991).
Chem. Pharm. Bull, "Synthesis and Mitogenic Activity of Chiral Lipopeptide WS 1279 and Its Derivatives" Kurimura et al., 41 (11), pp. 1965-1970 (1993).
Chem. Pharm. Bull., "Synthesis of Biologically Active Pentapeptide Analogs of the N-Terminal Part of Lipoprotein From the Outer Membrane of Escherichia coli" Kurimura et al., 38 (4), pp. 1110-1112 (1990).
Peptide Chemistry 1990: Y. Shimonishi (Ed.), Protein Research Foundation, Osaka, Japan (1990), "Synthesis and Mitogenic Activity of Lipopeptide and Its Analogs" Kurimura et al., pp. 37-42.
Peptide Chemistry 1991: A. Suzuki (Ed.) Protein Research Foundation, Osaka, Japan (1991), "Stereospecific Synthesis and Mitogenic Activity of Lipopeptide WS 1279 and Its Derivatives" Kurimura et al., pp. 361-366.
Int. J. Peptide Protein Res., "Synthesis of Novel Immunologically Active Tripalmitoyl-S-Glycerylcysteinyl Lipopeptides as Useful Intermediates for Immunogen Preparations" Metzger et al., 37, 1991, pp. 46-57.
Harada Setsuo
Hida Tsuneaki
Tanida Seiichi
Wakimasu Mitsuhiro
Yukishige Koichi
Huff Sheela J.
Takeda Chemical Industries Ltd.
Warden Jill
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