2-Amino-5-phenyl-1,3-benzodiazepines

Details 2-Amino-5-phenyl-1,3-benzodiazepines 2-Amino-5-phenyl-1,3-benzodiazepines

1984-02-07

1985-11-19

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

260239BD, 2603309, 544359, 548518, A61K 3155, C07D24304, C07D40312, C07D40304

Patent

active

045542732

ABSTRACT:
Disclosed are 2-amino-5-phenyl-1,3-benzodiazepines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, halogen, alkyl, or alkoxy; R.sub.2 being able to occupy any of the possible positions on the aromatic ring; R.sub.3 is hydrogen or alkyl; and R.sub.4 is hydrogen, alkyl, cycloalkyl, arylalkyl, heteroarylalkyl, dialkylaminoethyl, dialkylaminopropyl, (1-ethyl-2-pyrrolidino) methyl, dialkylamino, alkoxycarbonyl or cyano; or R.sub.3 and R.sub.4 form, with the adjacent nitrogen atom, a heterocycle having 5 to 7 side chains, optionally containing another heteroatom selected from oxygen, sulfur or nitrogen, this latter being able to be substituted by an alkyl group. The majority of the compounds are obtained by condensation of the corresponding 2-methylthio benzodiazepine hydroiodide with an appropriate amine. The compounds are useful as antidepressants.

REFERENCES:
patent: 3681340 (1972-08-01), Rodriguez et al.
patent: 3780023 (1973-12-01), Suh et al.
patent: 3780024 (1973-12-01), Suh et al.
patent: 3838122 (1974-09-01), Suh et al.
Diazepam, The Merck Index, 9th Edition, 1976, p. 394, No. 2961.

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