2-Amino-5-hydroxy-4-methylpyrimidine derivatives

Details 2-Amino-5-hydroxy-4-methylpyrimidine derivatives 2-Amino-5-hydroxy-4-methylpyrimidine derivatives

1983-10-03

1985-11-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514273, 544298, A61K 31505, C07D23947

Patent

active

045542767

ABSTRACT:
Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted amino derivatives thereof useful as inhibitors of leukotriene synthesis for the treatment of pulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In addition these compounds are cytoprotective and therefore useful in the treatment of peptic ulcers. A process for the preparation of such active compounds by ring rearrangement of 2-amino-5-acetyloxazole, pharmaceutical compositions containing the novel active compounds and compositions containing these compounds in combination with other anti-inflammatory agents or gastric anti-secretory agents.

REFERENCES:
patent: 4374136 (1983-02-01), Hill et al.
patent: 4416885 (1983-11-01), Huve
patent: 4435396 (1984-03-01), LaMattina et al.
Asadov; D. A., Chemical Abstracts, 70:2232w, (1969).
Esanu; Andre, Chemical Abstracts, 94:103410d, (1981).

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