2-Amino-5-aminomethyl-2-oxazolines, compositions and use

Details 2-Amino-5-aminomethyl-2-oxazolines, compositions and use 2-Amino-5-aminomethyl-2-oxazolines, compositions and use

1983-10-05

1985-02-05

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514218, 514237, 514252, 514340, 514364, 514377, 544137, 544360, 544369, 546148, 546193, 546209, 546281, 548233, C07D26328, C07D29512, A61K 3142, A61K 31535

Patent

active

044978120

ABSTRACT:
This invention relates to new 2-amino-5-aminomethyl-2-oxazolines, the method of preparing them, and their pharmacological properties making possible their application in cardiovascular, psychotropic, antiinflammatory antiallergic, antihistamine, antiH.sub.2 therapy.
These new products have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 independently represent an alkyl radical of C.sub.1 to C.sub.4, or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R.sub.1 and R.sub.2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms, and either 1 or 0 oxygen atoms. This heterocycle can be substituted by R with R being a lower alkyl, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trifluoromethyl, methyl, methoxy, hydroxy.

REFERENCES:
patent: 3299089 (1967-01-01), Zimmermann et al.

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