2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxyli

Details 2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxyli 2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxyli

1982-05-12

1984-10-09

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 47, C07D41712, A61K 3154

Patent

active

044761244

ABSTRACT:
Novel syn isomers of optically active isomers and racemates of 7-[2-(2-amino-4-thiazolyl)-2-oxyimino-acetamido]-bicyclooctene-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 6 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, methyl, halomethyl, hydroxymethyl and acyloxymethyl, X is selected from the group consisting of oxygen and optionally oxidized sulfur, A is selected from the group consisting of hydrogen, an alkali metal, --NH.sub.4, alkaline earth metal equivalent, a non-toxic, pharmaceutically acceptable organic amine and an easily cleavable ester group and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and their preparation.

REFERENCES:
patent: 4103086 (1978-07-01), Gleason et al.
Douglas et al.; Canadian Jour. of Chemistry, vol. 56, pp. 2879-2883, (1978).
Doyle et al., Canadian Jour. of Chemistry, vol. 58, pp. 2508-2523, (1980).

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