2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics

Details 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics

1990-03-29

1991-09-24

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514324, 514422, 514443, 514467, 514469, 548525, 549 57, 549 58, C07D2076, A61K 3134, A61K 3138, A61K 3140

Patent

active

050514288

ABSTRACT:
The invention concerns a series of novel 2-amino-monomethoxycyclohexyl amides having analgesic and neuroprotective activity. The compounds bind selectivity to the kappa opioid receptor. Pharmaceutical compositions containing the compounds, methods of using them, and processes for preparing them are also disclosed.

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J. Pharmacol. Exp. Ther., 197:517-532 (1976).
J. Pharmacol. Exp. Ther., 224:7-12 (1983).

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