Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1991-07-19
1993-01-05
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514484, 514513, 514531, 514562, 514563, 514570, 514616, 558251, 558254, 558255, 560 1, 560 16, 560 38, 560 39, 560 41, 560105, 560106, 560115, 560118, 560122, 560123, 560124, 560250, 562426, 562443, 562444, 562450, 562500, 562506, 564153, 564154, 564155, 564157, A61K 3119
Patent
active
051771098
ABSTRACT:
Compounds, compositions and methods are described for treating a CNS disorder such as a cognitive disorder, epilepsy, depression, Parkinson's disease, Alzheimer's disease, a neurodegenerative disease or neurotoxic injury. Compound of interest are 2-amino-4,5-methyleneadipic acid compounds and derivatives defined by the formula I: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, arylthioalkyl, ##STR2## with each of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein each of X and Y is independently selected from hydroxyl, alkoxy, alkylthio, amino and ##STR3## with each of R.sup.6 and R.sup.7 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein any of R.sup.1 through R.sup.7 groups having a substitutable position may be substituted with one or more substituents selected from hydroxyl, halo, alkyl, haloalkyl, cyano, alkoxy, alkylthio, sulfinyl, sulfonyl, sulfinylalkyl, sulfonylalkyl, amino, acyl, acyloxy, alkoxycarbonyl and aminocarbonyl; or a pharmaceutically-acceptable salt thereof.
REFERENCES:
S. M. Rothman and J. W. Olney, Annals of Neurology, 19, 105-111 (1986).
M. N. Perkins et al, Neuroscience Letters, 23, 333-336 (1981).
J. Davies et al, Neuroscience Letters, 21, 77-81 (1981).
K. Matoba et al, Chem. Pharm. Bull., 32, (10), 3918-3925 (1984).
L. Fowden et al, Phytochemistry, 8, 437-443 (1969).
K. Yamanoi et al, Tetrahedron Letters, 29, 1181-1184 (1988).
6th Camerino-Noordwijkerhout Symposium: Recent Advances in Receptor Chemistry Abstracts, Camerino, Italy, 73-74 (1987).
Cordi Alexis A.
Lanthorn Thomas H.
Marinozzi Maura
Monahan Joseph B.
Natalini Benedetto
G. D. Searle & Co.
Keane J. Timothy
Matukaitis Paul D.
Shippen Michael L.
Smith Charles E.
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