2-Amino-4-(4-pyridinyl)benzoic acids

Details 2-Amino-4-(4-pyridinyl)benzoic acids 2-Amino-4-(4-pyridinyl)benzoic acids

1983-07-08

1985-07-02

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546156, 546296, 546300, C07D21170, C07D21516

Patent

active

045269750

ABSTRACT:
2-Amino-4-(4-pyridinyl)benzoic acids, such as 2-amino-4-(4-pyridinyl)benzoic acid, are prepared by treating the appropriate 4-(4-alkyl-3-nitrophenyl)pyridine with an alcoholic base, such as methanolic potassium hydroxide. The products are particularly useful in the preparation of antibacterial 1-alkyl-1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids.

REFERENCES:
patent: 3753993 (1973-08-01), Lesher et al.
patent: 3907808 (1975-09-01), Lesher et al.
patent: 4118557 (1978-10-01), Lesher
patent: 4398029 (1983-08-01), Irikura et al.
Mitscher et al., J. Med. Chem. 1978, vol. 21, No. 5, pp. 485-489.

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