2-Amino-3-functionalized tetralin derivatives and related...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S419000, C514S422000, C514S423000, C514S323000, C514S339000, C546S201000, C546S278100, C548S492000, C548S506000, C548S516000, C548S510000, C548S494000, C548S953000

Reexamination Certificate

active

07365061

ABSTRACT:
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia, impaired glucose tolerance, insulin resistance and hyperinsulinemia), the microvascular complications associated with diabetes (such as retinopathy, neuropathy, nephropathy and delayed wound healing), the macrovascular complications associated with diabetes (cardiovascular diseases such as atherosclerosis, abnormal heart function, myocardial ischemia and stroke), as well as Metabolic Syndrome and its component conditions including hypertension, obesity and dislipidemia (including hypertriglyceridemia, hypercholesterolemia and low HDL), and other maladies such as non-cardiac ischemia, infection and cancer. These novel compounds have the structureor stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, R1, R2, X, Y and Z are defined herein.

REFERENCES:
patent: 5952322 (1999-09-01), Hoover et al.
patent: 5998463 (1999-12-01), Hulin et al.
patent: 6589970 (2003-07-01), Commons et al.
patent: 2001/0046958 (2001-11-01), Treadway
patent: 2003/0073731 (2003-04-01), Lee
patent: 2004/0002495 (2004-01-01), Sher et al.
patent: 978 279 (2000-02-01), None
patent: 1 041 068 (2000-10-01), None
patent: 1 149 580 (2001-01-01), None
patent: 1 088 824 (2001-04-01), None
patent: 1 136 071 (2001-09-01), None
patent: 1 177 791 (2002-02-01), None
patent: WO 96/39384 (1996-12-01), None
patent: WO 96/39385 (1996-12-01), None
patent: WO 99/26659 (1999-06-01), None
patent: WO 99/43663 (1999-09-01), None
patent: WO 00/15645 (2000-03-01), None
patent: WO 00/47206 (2000-08-01), None
patent: WO 01/23347 (2001-04-01), None
patent: WO 01/32622 (2001-05-01), None
patent: WO 02/20530 (2002-03-01), None
patent: WO 02/064546 (2002-08-01), None
patent: WO 02/064565 (2002-08-01), None
patent: WO 03/035621 (2003-05-01), None
patent: WO 03/037864 (2003-05-01), None
patent: WO 03/072570 (2003-09-01), None
patent: WO 03/074484 (2003-09-01), None
patent: WO 03/074513 (2003-09-01), None
patent: WO 03/074531 (2003-09-01), None
patent: WO 03/074532 (2003-09-01), None
patent: WO 03/091213 (2003-11-01), None
patent: WO 03/104188 (2003-12-01), None
patent: WO 2004/041780 (2004-05-01), None
patent: WO 2004/072060 (2004-08-01), None
patent: WO 2004/078743 (2004-09-01), None
Co-pending U.S. Appl. No. 11/273,445, filed Nov. 14, 2005.
Co-pending U.S. Appl. No. 11/273,479, filed Nov. 14, 2005.
Co-pending U.S. Appl. No. 11/272,845, filed Nov. 14, 2005.
Proc. Natl. Acad. Sci. USA 1998, 95, 1776-1781.
J. Med. Chem. 1998, 41, 2934-2938.
Exp. Opin. Invest. Drugs 2001, 10, 439-454.
J. Med. Chem. 2002, 45, 1002-1018.
Journal of Pharmaceutical Sciences, vol. 64(6), 1975, 1001-1005.

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