2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids

Details 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids

1983-11-22

1985-03-05

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514562, 560 9, 562426, C07C14943, A61K 3124, A61K 31195

Patent

active

045030731

ABSTRACT:
Novel 2-amino-3-(alkylthiobenzoyl)phenylacetic acids, esters and metal salts have the formula: ##STR1## wherein R is hydrogen or lower alkyl, R.sup.1 is hydrogen, lower alkyl or pharmaceutically acceptable metal cation, R.sup.2 is hydrogen, halogen, lower alkyl or lower alkoxy, Am is primary amino (--NH.sub.2), methylamino or dimethylamino. The compounds have anti-inflammatory activity; have effective analgesic activity, and inhibit blood platelet aggregation.

REFERENCES:
patent: 3828093 (1974-08-01), Bays
patent: 3880916 (1975-04-01), Dickel
patent: 3975531 (1976-08-01), Welstead
patent: 4021469 (1977-05-01), Weston
patent: 4045575 (1977-08-01), Welstead
patent: 4126635 (1978-11-01), Welstead
Lowy, "An Introduction to Organic Chemistry," 4th Ed., pp. 198-199, (1936).

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