2-amino-3-(alkyl)-pyrimidone derivatives

Details 2-amino-3-(alkyl)-pyrimidone derivatives 2-amino-3-(alkyl)-pyrimidone derivatives

2008-05-27

2008-05-27

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S211150, C514S272000, C514S273000, C540S544000, C540S575000, C544S320000, C544S321000

Reexamination Certificate

active

07378413

ABSTRACT:
A pyrimidone derivative represented by formula (I) or a salt thereof:Wherein:R1 represents a hydrogen atom or a C1-6alkyl group which may be substituted by a C6,10aryl group;R2 represents a C1-10alkyl group which may be substituted, a C2-6alkenyl group which may be substituted, a C3-6alkynyl group which may be substituted, a C3-6cycloalkyl group which may be substituted, or a C6-10ARYL group which may be substituted;or R1 and R2 form together a C2-6alkylene group which may be substituted;or R1 and R2 form together a chain of formula —(CH2)2—X—(CH2)2— or —(CH2)2—X—(CH2)3— where X represents a oxygen atom, a sulfur atom, or a nitrogen atom which may be substituted;R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4alkyl group, C1-4alkoxy group or halogen atom; andR4 represents a C1-10alkyl group optionally substituted by a hydroxyl group, amino, C1-6monoalkylamino group, C2-12dialkylamino group or C6,10aryl group which may be substituted.And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease.

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