2-amino-3,5-di-(halomethyl)-pyrazines and their preparation

Details 2-amino-3,5-di-(halomethyl)-pyrazines and their preparation 2-amino-3,5-di-(halomethyl)-pyrazines and their preparation

1985-09-16

1987-09-08

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544336, C07D40304, C07D24120

Patent

active

046925279

ABSTRACT:
2-Amino-3,5-di-(halomethyl)-pyrazines of the general formula I ##STR1## where X is either chlorine or bromine, m and n may each be 0, 1, 2 or 3 and R.sup.1 and R.sup.2 are each hydrogen or a protective group or may furthermore be bonded to one another, in particular those compounds of the formula I in which m is 1 and n is 2 and/or R.sup.1 and R.sup.2 together form a phthaloyl radical, are useful intermediates for the pteridine building block of folic acid or folic acid analogs.
They are obtained by a method in which a 2-amino-3,5-dimethylpyrazine of the general formula II ##STR2## is treated with a chlorinating or brominating agent and, where R.sup.1 and/or R.sup.2 are protective groups, these are, if desired, eliminated when the chlorination or bromination is complete.

REFERENCES:
patent: 3320126 (1967-05-01), Meltzer
Hirschberg, et al., J. Organic Chem., vol. 26, (1961) pp. 2356-2360.
Sharp, et al., Chem. Abstracts, vol. 46, (1952), entry 2083h.
E. C. Taylor et al., J. Org. Chem. vol. 43, No. 4, 1978, p. 736.
E. C. Taylor et al., J. Org. Chem. 45, 1980, pp. 2485 to 2489.
E. C. Taylor et al., J. Org. Chem. 46, 1981, pp. 1394 to 1402.
Houben-Weyl, Methoden der Org. Chemie, vol. 5/3, Georg-Thieme Verlag Stuttgart, 1962, pp. 728, 731, 748.

Affiliated with

Also associated with

Rating

2-amino-3,5-di-(halomethyl)-pyrazines and their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-amino-3,5-di-(halomethyl)-pyrazines and their preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-amino-3,5-di-(halomethyl)-pyrazines and their preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2159033