2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni

Details 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni

1980-07-21

1981-10-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546334, C07D21330, A61K 3144

Patent

active

042973635

ABSTRACT:
2-Amino-3(4 or 5)-PY-phenol, a cardiotonic agent, is prepared by reducing 2-nitro-3(4 or 5)-PY-phenol, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. 2-Amino-3(4 or 5)-PY-phenol or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 4-amino-5-(4-pyridinyl)phenol is shown for comparative purposes.

REFERENCES:
patent: 3753993 (1973-08-01), Lesher et al.
patent: 3907808 (1975-09-01), Lesher et al.
Heilbron, et al, J. Chem. Soc., 1940, pp. 1279-1284.
Coates, et al., J. Chem. Soc., 1943, pp. 406-413.

Affiliated with

Also associated with

Rating

2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotoni will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-279473