[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid deriva

Details [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid deriva [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid deriva

1991-12-17

1992-12-01

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 540542, 540567, 540473, 544337, 544349, A61K 3155, C07D22312, C07D24136, C07F 902

Patent

active

051681030

ABSTRACT:
A compound of the formula: ##STR1## in which R.sup.1 is hydrogen, alkyl or phenylalkyl; R.sup.2 is hydrogen, alkyl, alkenyl or phenylalkyl; or R.sup.1 and R.sup.2 taken together are --Ch.sub.2 CH.sub.2 --, --CH.sub.2 C(R.sup.6)(R.sup.7)CH.sub.2 --or --CH.sub.2 C(R.sup.8)(R.sup.9)--C(R.sup.10)(R.sup.11)CH.sub.2 --, where R.sup.6, R.sup.8 and R.sup.10 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms or hydroxyl and R.sup.7, R.sup.9 and R.sup.11 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms; A is alkylene or alkenylene; X is CO.sub.2 R.sup.3 in which R.sup.3 is hydrogen or alkyl, P(O)(OR.sup.4)(OR.sup.5) in which R.sup.4 and R.sup.5 are, independently, hydrogen or alkyl, 3,5-dioxo-1,2,4-oxadiazolindin-2-yl or 5-tetrazolyl; or a pharmaceutically acceptable salt thereof are useful as neuroprotectants.

REFERENCES:
CA 114:246836q Squaric acid . . . diamides. Tietze et al. p. 717. 1991.

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