(2-Amino-2-oxoethoxy)acetic acid compounds, compositions and met

Details (2-Amino-2-oxoethoxy)acetic acid compounds, compositions and met (2-Amino-2-oxoethoxy)acetic acid compounds, compositions and met

1977-08-30

1978-10-31

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424316, 424319, 544129, 544130, 26029376, 26029386, 2605011, 26050116, 26050117, 562444, 562449, 562503, 562507, 562502, C07D21116, A61K 31445

Patent

active

041235380

ABSTRACT:
Novel (2-amino-2-oxoethoxy)acetic acid compounds and antisecretory compositions and methods employing (2-amino-2-oxoethoxy)acetic acid compounds are disclosed. The (2-amino-2-oxoethoxy)acetic acid compounds are also useful as cardiotonic agents and as calcium binding agents; certain of the compounds are also useful for their calcium transport properties. Novel 4-substituted 3,5-morpholinediones intermediates in the preparation of certain of the (2-amino-2-oxoethoxy)acetic acid compounds and further useful as antisecretory agents are also disclosed.

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Baron et al., "J. Med. Chem." 10, (1967), pp. 276-279.
Baron et al., "Syn of Sub. Morpholinediones as Pot. CNS Depressants" Thesis, pp. 41-42, 84, 107-109, 115-117 Anschutz "Ann Chem" 259 (1890), 187-193.
Sido, "Bev. deut. Pharm. Ges." (1921), 31, p. 118.
Bennett et al., "J. Med. Chem." 19 (1976), pp. 709-714.

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