2-amino-1,4-dihydropyridine derivatives with calcium agonist and

Details 2-amino-1,4-dihydropyridine derivatives with calcium agonist and 2-amino-1,4-dihydropyridine derivatives with calcium agonist and

1990-07-09

1992-11-24

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544212, 544238, 544295, 544333, 544357, 544360, 544362, 544364, 544365, 546116, 546256, 546258, 546283, 546310, A61K 31495, C07D40310, C07D40110

Patent

active

051661489

ABSTRACT:
There are provided novel 1,4-dihydropyridine compounds possessing both calcium agonist and alpha.sub.1 -antagonist activity useful for treating congestive heart failure, pharmaceutical compositions containing them and methods of using these compounds to treat congestive heart failure in a mammal.

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patent: 4537881 (1985-08-01), Heiker et al.
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patent: 4886819 (1989-12-01), Ashimori et al.
patent: 4937242 (1990-06-01), Matsui et al.
M. Schram, et al. Nature 303:535 (1983).
M. Schram, et al. Arzneim-Forsch 33:1268 (1983).
P. Erne et al., Biochem. Biophys. Res. Commun. 118:842 (1984).

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