2-amino-1,3-propanediol compound and immunosuppressant

Details 2-amino-1,3-propanediol compound and immunosuppressant 2-amino-1,3-propanediol compound and immunosuppressant

1996-10-02

1998-02-17

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514459, 514471, 514561, 514564, 564123, 564336, 564340, 564342, 564346, 564374, 564383, 564459, C07C71100, A01N 4340, A01N 3302

Patent

active

057191760

ABSTRACT:
A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branched carbon chain, optionally substituted aryl or optionally substituted cycloalkyl; and R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which may be the same or different from one another, represent each hydrogen, alkyl, aralkyl, acyl or alkoxycarbonyl. The compound is immunodepressant and useful as an inhibitor against rejection in organ or bone marrow transplantation, as a preventive or remedy for autoimmune diseases and so forth, or a reagent in the medical and pharmaceutical fields. ##STR1##

REFERENCES:
patent: 4499221 (1985-02-01), Saitoh et al.
patent: 5068247 (1991-11-01), Fujita et al.

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