2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity

Details 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity

1984-05-15

1987-09-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548484, A61K 31405, C07D20934

Patent

active

046940170

ABSTRACT:
Novel oxindole derivative and salt thereof represented by the general formula, ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; R.sup.2 is a hydrogen atom or a lower alkyl group; R.sup.3 is a hydrogen atom, a cycloalkylcarbonyl group, a benzoyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group on the phenyl ring, or a phenyl-lower alkanoyl group which may have halogen atoms as the substituents on the phenyl ring; provided that when R.sup.4 is a hydrogen atom, then R.sup.3 should be neither a hydrogen atom nor a lower alkyl group.
The novel oxindole derivative and salt thereof possesses anti-peptic ulcer effects and are useful as anti-peptic ulcer agents.

REFERENCES:
patent: 4000297 (1976-12-01), Rovati
Kotake, M. et al., J. Amer. Chem. Soc. (1950), v. 72, pp. 5085-5087.
Ariens, E. S., Drug Design, Academic Press, New York (1971) p. 10.
Burger, Alfred, Medicinal Chemistry, John Wiley & Sons, New York, (1971) pp. 803-804.
McOmie, J. F. W., Protective Groups in Organic Chemistry, Plenum Press (1973) pp. 46-51.
Ohno, et al., . . . Synthesis 1,2 Hydroxytryptamine, and its Derivatives," J. Org. Chem., vol. 17, pp. 2635-2637 (1974).

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