2-amido-3-aminocarboxylic acid esters and process of preparation

Details 2-amido-3-aminocarboxylic acid esters and process of preparation 2-amido-3-aminocarboxylic acid esters and process of preparation

1985-03-06

1986-06-03

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 27, 560 29, 560 32, 560 35, 560 38, 560115, 560168, C07C10102, C07C125065

Patent

active

045931186

ABSTRACT:
2,3-Diaminocarboxylic acid compounds are prepared by (A) nitrosating a .beta.-keto ester to form a 3-keto-2-oximino ester, (B) converting the resultant oxime to a protected 2-amine, (C) reductively aminating the 3-position of the protected 2-amine to form a 2,3-diaminocarboxylic acid ester wherein the 2-amino group is protected, and (D) when desired, treating the 2,3-diaminocarboxylic acid ester to deprotect one or more of the amino and carboxyl groups.

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