2-alkynyladenosines as antihypertensive agents

Details 2-alkynyladenosines as antihypertensive agents 2-alkynyladenosines as antihypertensive agents

1988-12-12

1990-09-11

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 23, 536 24, 536 26, A61K 3170, C07H 19167

Patent

active

049563459

ABSTRACT:
A 2-alkynyladenosine represented by general formula [I]: ##STR1## wherein n is an integer of from 2 to 15, has been found to have excellent properties as an antihypertensive agent. On the basis of this finding, the present invention has provided an antihypertensive agent comprising an antihypertensive effective amount of a compound of the above formula [I] and a pharmaceutically acceptable carrier. The present invention also discloses a novel compound 2-alkynyladenosine of formula [I] shown above wherein n is 6 to 15.

REFERENCES:
Matsuda et al., (I), Chem. Pharm. Bull., vol. 33(4), pp. 1766-1769, 1985 (Apr.).
Matsuda, et al. II, Chem. Abstr., vol. 101, 23865d, 1984(7/6).
Matsuda et al. III, Chem. Abstr., vol. 103, 196359m, 1985, (Chem. Abstr. Report of Ref. R).
Matsuda et al. IV, Chem. Abstr., vol. 104, 101950f, 1985.
Marumoto et al., Chem. Pharm. Bull., vol. 23(4), pp. 759-774 (1975).
Angus et al., Br. J. Pharmac., vol. 41, pp. 592-599 (1971).
Goodman et al., "The Pharmacological Basis of Therapeutics", 6th ed., 1980, MacMillan Publishing Co., New York, p. 799.

Affiliated with

Also associated with

Rating

2-alkynyladenosines as antihypertensive agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-alkynyladenosines as antihypertensive agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-alkynyladenosines as antihypertensive agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1184879