2-alkynyl- and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S267000, C544S251000

Reexamination Certificate

active

11135261

ABSTRACT:
Compounds having the structural formula Ior a pharmaceutically acceptable salt thereof, whereinR isR1, R2, R3, R4and R5are H, alkyl or alkoxyalkyl;R6is H, alkyl, hydroxyalkyl or —CH2F;R7, R8and R9are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or —CF3; andZ is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed.Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

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