Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-24
2005-05-24
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S267000, C544S251000
Reexamination Certificate
active
06897217
ABSTRACT:
Compounds having the structural formula Ior a pharmaceutically acceptable salt thereof, whereinR isR1, R2, R3, R4and R5are H, alkyl or alkoxyalkyl;R6is H, alkyl, hydroxyalkyl or —CH2F;R7, R8and R9are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or —CF3; andZ is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed.Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
REFERENCES:
patent: 5565460 (1996-10-01), Suzuki et al.
patent: 20020099061 (2002-07-01), Neustadt et al.
patent: WO 9501356 (1995-01-01), None
patent: WO 9705138 (1997-02-01), None
patent: WO9852568 (1998-11-01), None
patent: WO 0192264 (2001-12-01), None
patent: WO 02055083 (2002-07-01), None
patent: WO 03032996 (2003-04-01), None
Ongini et al., PubMed Abstract (Ann N Y Acad Sci. 825:30-48), Oct. 1997.*
Layzer, Degenerative Diseases of the Nervous System, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-2057, 1996.*
Damasio, Alzheimer's Disease and related dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.*
Baraldi et al,J. Med. Chem., 43(2000) 4768-80.
Baraldi et al,Bioorganic and Med. Chem. Let., 4(21) (1994) 2539-44.
U.S. Appl. No. 10/738,906, filed Dec. 17, 2003, Grezlak et al.
Baraldi et al,J. Med. Chem., 39(1996), 1164-1171.
Huang et al,Tet. Lett., 40(1999), 8647-8650.
Varelis et al,Aust. J. Chem., 48(1995), 1775-1779.
Kanth et al,J. Org. Chem., 56(1991), 5964-5965.
Orito et al,Synthesis, 23(1997), 23-25.
Aiba et al,Bioorg. Med. Chem. Lett., 11(2001), 2783-2786.
Baum et al,J. Org. Chem., 48(1983), 2953-2956.
Cornelius et al,Synth. Commun., 24, (19) (1994), 2777-2788.
Lee et al,Synth. Commun., 33, (9) (2003), 1611-1614.
Ungerstedt et al,Brain Research, 24(1970), 485-493.
Ungerstedt,Eur. J. Pharmacol., 5(1968), 107-110.
Boyle Craig D.
Chackalamannil Samuel
Hao Jinsong
Liu Hong
Neustadt Bernard R.
Magatti Anita W.
Rao Deepak
Schering Corporation
LandOfFree
2-Alkynyl-and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-Alkynyl-and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-Alkynyl-and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3388083