2-Alkynyl-5-indanyloxyacetic acids

Details 2-Alkynyl-5-indanyloxyacetic acids 2-Alkynyl-5-indanyloxyacetic acids

1979-04-09

1981-01-27

Garner, Vivian

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

2603265C, 2603268, 2604299, 260439R, 260448R, 2604488R, 26050115, 26050116, 260590FA, 42424853, 424250, 424267, 424274, 424287, 424289, 424295, 424316, 424317, 544107, 544403, 546206, 560 53, C07C 5990

Patent

active

042477158

ABSTRACT:
Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.

REFERENCES:
patent: 3974212 (1976-08-01), Cragoe, Jr. et al.
patent: 3984465 (1976-10-01), Cragoe, Jr. et al.
patent: 4070539 (1978-01-01), Cragoe, Jr. et al.
patent: 4096267 (1978-06-01), Cragoe, Jr. et al.
de Solms et al., J. Med. Chem., 21, 437-443 (1978).
Waltersdorf, Jr. et al., J. Med. Chem., 20, 1400-1408 (1977).

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