2-Alkynyl-5-indanyloxyacetic acids

Details 2-Alkynyl-5-indanyloxyacetic acids 2-Alkynyl-5-indanyloxyacetic acids

1981-05-21

1982-06-08

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5976

Patent

active

043340881

ABSTRACT:
Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.

REFERENCES:
patent: 3984465 (1976-10-01), Cragoe et al.
patent: 4070539 (1978-01-01), Cragoe
patent: 4096267 (1978-06-01), Cragoe et al.
de Solms et al., "J. Med. Chem.", 21, pp. 437-443, 1978.
Woltersdorf et al., "J. Med. Chem.", 20, pp. 1400-1408, 1977.

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