2-Alkylsulfinyl-4(3H)-quinazolinone derivatives and pharmaceutic

Details 2-Alkylsulfinyl-4(3H)-quinazolinone derivatives and pharmaceutic 2-Alkylsulfinyl-4(3H)-quinazolinone derivatives and pharmaceutic

1988-01-26

1989-05-23

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544284, 544285, A61K 31505, C07D23995, C07D40312

Patent

active

048331449

ABSTRACT:
2-Alkylsulfinyl-4(3H)-quinazolinone derivatives of formula (I) are provided. ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl group, an aryl group, a substituted aryl group or an aralkyl group, R.sub.2 is a phenyl group, a substituted phenyl group or a 5- or 6-membered heterocyclic group containing one or more N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring, n is 1 or 2 and X is hydrogen, a C.sub.1 -C.sub.6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

REFERENCES:
patent: 4576941 (1986-03-01), Suh et al.
patent: 4605657 (1986-08-01), Edwards
Chan, "Chemical Abstracts", vol. 95, 1981, col. 95:6504a.
Benneche et al., "Chemical Abstracts", vol. 97, 1982, col. 97:182352z.
Southon et al., "Chem. Ber.," Band 111 (3), 1978, pp. 1006-1018.
J. Chem. Soc., vol. 82, p. 964 (1960).
J. Med. Chem., vol. 26, 218-222 (1983).
Chem. Abstract, vol. 83, 131542 q (1975).
Chem. Abstract, vol. 92, 146713 F (1980).
Chem. Abstract, vol. 91, 39422t (1979).

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