2'-alkylidenepyrimidine nucleoside derivatives, process for prod

Details 2'-alkylidenepyrimidine nucleoside derivatives, process for prod 2'-alkylidenepyrimidine nucleoside derivatives, process for prod

1993-09-24

1995-07-04

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 1906

Patent

active

054301394

ABSTRACT:
Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

REFERENCES:
patent: 5300636 (1994-04-01), Matsuda et al.

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