2'-alkylidenepyrimidine nucleoside compounds and a process for p

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 1906

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053006364

ABSTRACT:
Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## wherein R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof.
These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent.
Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

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patent: 5047520 (1991-09-01), Matsuda et al.
Beres et al., J. Med. Chem. 1986, 29, 1243-1249.
Brodbeck et al., J. Org. Chem. vol. 35, No. 10, 3552-3558 (1970).
Hansske et al., Tetraedron, vol. 40, No. 1, pp. 125-134 (1984).
Matsuda et al., Chem. Pharm. Bull., vol. 36, No. 3, pp. 945-953(1988).

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