2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyrid

Details 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyrid 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyrid

1986-09-03

1987-07-07

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, 546263, 546271, 546283, C07D21190, C07D40112, C07D40512, A61K 31455

Patent

active

046787968

ABSTRACT:
Novel 2-(2-alkoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-[2-(substituted )phenyl]-3,5-pyridinedicarboxylic acid dialkyl ester derivatives having novel inotropic and hypotensive activity, processes for their manufacture, pharmaceutical compositions, and methods for using said compounds and compositions are described.

REFERENCES:
patent: 3905983 (1975-09-01), Bossert et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
Loev, B. et al., J. Med. Chem. (1974), vol. 17, No. 9, pp. 956-965.
Meyer, H., Calcium Antagonists and Cardiovascular Disease, edited by L. H. Opie, Raven Press, New York (1984).
Schramm et al., "Novel Dihydropyridine, with Positive Inotropic Action", Nature, vol. 303, Jun. 9, 1983 (pp. 535-537).

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