2-alkylidene-aminoguanidines and methods of use therefor

Details 2-alkylidene-aminoguanidines and methods of use therefor 2-alkylidene-aminoguanidines and methods of use therefor

1991-05-07

1992-07-14

Cintins, Marianne

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514614, 514634, 514565, 424 54, A01N 4340, A01N 3752, A01N 3712, A61K 3144, A61K 3116, A61K 31155, A61K 722

Patent

active

051303248

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain 2-alkylidene aminoguanidines and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 3592935 (1971-07-01), Houlihan et al.
patent: 3896232 (1975-07-01), Houlihan et al.
patent: 3975533 (1976-07-01), Kodama et al.
patent: 4006249 (1977-02-01), Porter et al.

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