2-alkyl-thioergolines and their use for treating anxiety

Details 2-alkyl-thioergolines and their use for treating anxiety 2-alkyl-thioergolines and their use for treating anxiety

1985-10-28

1988-01-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, A61K 3148, C07D45702

Patent

active

047204982

ABSTRACT:
There is described a compound of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-4 alkyl, R.sup.2 is hydrogen, C.sub.1-4 alkyl, hydroxy C.sub.1-4 alkyl, C.sub.1-4 alkoxy C.sub.1-4 alkyl, HSC.sub.1-4 alkyl, C.sub.1-4 alkyl-S-C.sub.1-4 alkyl, C.sub.1-4 alkylthio, optionally substituted arylthio or optionally substituted aralkylthio, and R.sup.3 is hydrogen, C.sub.1-4 alkyl, optionally substituted aryl or optionally substituted aralkyl; and salts thereof. The compounds show useful effects on the central nervous system.

REFERENCES:
patent: 3029243 (1962-04-01), Olin
patent: 3901894 (1975-08-01), Kornfeld et al.
patent: 4229450 (1980-10-01), Ferrari et al.
patent: 4382940 (1983-05-01), Bernardi et al.
Derwent 80235A/45, Abstracting Belgian 868,768.
Derwent 64222W/39, Abstracting DT 2,509,471.
Derwent 20614C/12, Abstracting EPO 8,802.

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