2-Alkyl-4-substituted amino-quinazolines and nitrates thereof in

Details 2-Alkyl-4-substituted amino-quinazolines and nitrates thereof in 2-Alkyl-4-substituted amino-quinazolines and nitrates thereof in

1974-12-03

1976-05-04

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31505

Patent

active

039549879

ABSTRACT:
Disclosed are compounds of the class of quinazolines substituted at the 2-position by lower alkyl and at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-(5-hydroxypentyl) amino-2-methyl-6,7-dimethoxy-quinazoline nitrate. The compounds and their corresponding hydroxy intermediates have various pharmacological activities in animals and are useful, for example, as anti-anginal agents and as agents in the treatment of shock.

REFERENCES:
patent: 3449498 (1969-06-01), DeStevens et al.
patent: 3517005 (1970-06-01), Cronin et al.
patent: 3637699 (1972-01-01), Gabel et al.
patent: 3637700 (1972-01-01), Gabel et al.
patent: 3637701 (1972-01-01), Gabel et al.

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