2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles

Details 2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles 2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles

1974-11-27

1976-12-14

Higel, Floyd D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260141, 260248AS, 260309, 424226, A61I 2700, C07C11500

Patent

active

039975185

ABSTRACT:
Imidazoles of the formula: ##STR1## and their salts, wherein R.sub.1 is an optically substituted hydrocarbon, heterocyclic or thiol group; R.sub.2 is an amino or optionally substituted etherified hydroxyl group; R.sub.11 is a negative charge or alkyl group when R.sub.10 is N.sub.2 + or R.sub.11 is a hydrogen atom or alkyl group when R.sub.10 is N = N -- NR.sub.3 R.sub.4 where R.sub.3 is methyl or .beta.-chloroethyl and R.sub.4 is optionally substituted hydrocarbon. When R.sub.10 is N.sub.2 + the compounds are useful as intermediates in the synthesis of compounds wherein R.sub.10 is N=N-- NR.sub.3 R.sub.4 these latter compounds possessing anti-tumor and/or anti-microbial activity.

REFERENCES:
patent: 3649613 (1972-03-01), Krauth et al.
Shealy et al (I), J. Org. Chem., vol. 27, pp. 2150-2154 (1962).
Shealy et al (II), J. Med. Chem., vol. 9, pp. 34-38 (1966).
Shealy et al (III), J. Pharm. Sciences, vol. 56, pp. 147-148 (1967).
Shealy et al (IV), Nature, vol. 210, p. 208 (1966).

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