Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-02-08
2005-02-08
Qazi, Sabiha N. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C514S177000, C514S178000, C514S180000, C552S614000, C552S518000, C552S519000
Reexamination Certificate
active
06852710
ABSTRACT:
The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.
REFERENCES:
patent: 5504074 (1996-04-01), D'Amato et al.
patent: 5661143 (1997-08-01), D'Amato et al.
patent: 5892069 (1999-04-01), D'Amato et al.
patent: 6051726 (2000-04-01), Sachdeva et al.
patent: 6054598 (2000-04-01), Sachdeva et al.
patent: 6136992 (2000-10-01), Ram et al.
patent: 6162930 (2000-12-01), Pinney et al.
patent: 6414015 (2002-07-01), Mooberry et al.
patent: 6593321 (2003-07-01), Rao et al.
patent: WO 9504535 (1995-02-01), None
patent: WO 9840398 (1998-09-01), None
Breuer, H.; Knuppen, R. Biosynthesis of 2-Methoxyestradiol in Human Liver.Naturwissenschaften 1960, 12, 280-281.
Seegers, J. C.; Aveling, M.-L.; van Aswegan, C. H.; Cross, M.; Koch, F.; Joubert, W.S. The Cytotoxic Effects of Estradiol-17β, Catacholestradiols and Methoxyestradiols on Dividing MCF-7 and HeLa Cells. J.Steroid Biochem. 1989, 32, 797-809.
Fotsis, T.; Zhang, Y.; Pepper, M. S.; Adlercreutz, H.; Montesano, R.; Nawroth, P. P.; Schweigerer, L. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth.Nature 1994, 368, 237-239.
Cushman, M.; He, H.-M.; Katzenellenbogen, J. A.; Lin, C. M.; Hamel, E. Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site.J. Med. Chem. 1995, 38, 2041-2049.
Cushman, M.; He, H.-M.; Katzenellenbogen, J. A.; Varma, R. K.; Hamel, E.; Lin, C. M.; Ram, S. Sachdeva, Y. P. Synthesis of Analogs of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth. J.Med. Chem. 1997, 40, 2323-2334.
Axelrod, L. R.; Rao, P. N. Synthesis of 2-Hydroxyestradiol-17β.Chem. Ind. 1959, 1454-1455.
Axelrod, L. R.; Rao, P. N.; Goldzieher, J. W. The Conversion of 2-Hydroxyestradiol-17 β to 2-Hydroxy and 2-Methoxy Metabolites in Human Urine.Arch. Biochem. Biophys. 1961, 94, 265-268.
Rao, P. N.; Axelrod, L. R. 2-Hydroxy-(Estrogens. Part II. Synthesis of 2,3-Dihydroxy-(Estra- 1,3,5(10)-trien-17-one and (Estra-1,3,5(10)-triene-2,3,16α,17β -tetraol. J.Chem. Soc. 1961, 4769-4773.
Rao, P. N.; Jacob, E. J.; Axelrod, L. R. Total Synthesis of Polymethoxyoestrane Compounds. Part I. Synthesis of (±)-2,3,4-Trimethoxyoestra-1,3,5(10)-trien-17β -o1 and Related Compounds. J.Chem. Soc., Sect C. 1971, 2855-2860.
Rao, P. N.; Axelrod, L. R. Total Synthesis of Polymethoxyoestrane Compounds. Part II. Synthesis of (±)-2,4-Dimethoxyoestra-1,3,5(10)-trien-17β-o1. J.Chem. Soc., Sect C. 1971, 2861-2863.
Rao, P. N.; Burdett Jr., J. E. A Novel Two-Step Synthesis of 2-Methoxyestradiol.Synthesis1977, 168-169.
Rao, P. N.; Somawardhana, C. W. Synthesis of 2-Methoxy and 4-Methoxy Equine Estrogens.Steroids 1987, 49, 419-432.
Skehan, P.; Storeng, R.; Scudiero, D., Monks; A., McMahon, J.; Vistica, D., Warren, J. T.; Bokesch, H.; Kenney, S.; and Boyd, M. R. New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening.J. Natl. Cancer Inst. 1990, 82, 1107-1112.
Harrowven, D. C. Danity, R. F. Zirconium Tetrachloride as a Mediator for Ambient Temperature Ortho-Fries Rearrangements.Tetrahedron Lett. (1996), 37, 7659-7660.
Alberts, B. Bray, D., Lewis, J., Raff, M, Roberts, K., Watson,J. Molecurar Biology of the Cell, pp. 652-661 (1989).
Stryer, L.,Biochemistry(1988) pp. 938-947.
Cessac James W.
Mooberry Susan L.
Rao Pemmaraju Narasimha
Tinley Tina L.
Cox Smith Matthews Incorporated
Qazi Sabiha N.
Southwest Foundation for Biomedical Research
LandOfFree
2-alkoxyestradiol analogs with antiproliferative and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-alkoxyestradiol analogs with antiproliferative and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-alkoxyestradiol analogs with antiproliferative and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3471672