2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenz

Details 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenz 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenz

1986-03-05

1988-01-05

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514305, A61K 3144

Patent

active

047175630

ABSTRACT:
A method of controlling emesis caused by non-platinum anti-cancer drugs with 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is loweralkyl; and R.sub.2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

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