2-Alkoxy-n-(1-azabicyclo(2.2.2)oct-3-yl) benzamide and thiobenza

Details 2-Alkoxy-n-(1-azabicyclo(2.2.2)oct-3-yl) benzamide and thiobenza 2-Alkoxy-n-(1-azabicyclo(2.2.2)oct-3-yl) benzamide and thiobenza

1988-09-06

1989-10-31

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61U 3144

Patent

active

048777943

ABSTRACT:
2-Alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulphur; R.sub.1 is loweralkyl; and R.sub.2 is hydrogen, halo, 4,5-benzo, alkoxy or Am wherein Am is amino, methylamino or dimethylamino, and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof have antischizophrenic activity.

REFERENCES:
patent: 4093734 (1978-06-01), Kruger et al.
patent: 4593034 (1986-06-01), Munson, Jr. et al.
Mikhlina et al., Chem. Abstr. 65:2220b (1966).
Mikhlina et al., Chem. Abstr. 79:146358a (1973).
Mikhlina et al., Chem. Abstr. 86:155489r (1977).
Krueger, G. et al., Chem. Abstr. 87:68001(c) (1977).

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