2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof

Details 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof

1982-11-10

1984-07-31

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 546257, 546258, A61K 3144, C07D40104

Patent

active

044630085

ABSTRACT:
2-(R.sub.1 O)-3-Q-5-PY-6-R-pyridine (I) or pharmaceutically acceptable acid-addition salts thereof are useful cardiotonics, where R.sub.1 is methyl or ethyl, R is hydrogen or lower-alkyl, PY is 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, and Q is hydrogen, chloro or COOR' where R' is lower-alkyl, or Q is cyano only when R is hydrogen. The preparation of I and their cardiotonic use are shown.

REFERENCES:
patent: 3655679 (1972-04-01), Shen et al.
patent: 4107315 (1978-08-01), Lesher et al.
patent: 4137233 (1979-01-01), Lesher et al.
patent: 4225601 (1980-09-01), Lesher et al.
patent: 4225715 (1980-09-01), Lesher et al.
patent: 4312875 (1982-01-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.
patent: 4347363 (1982-08-01), Singh
Baker et al., [Drug Metab. Dispos., vol. 10, No. 2, pp. 168-172, (1982)].
P. Nantka-Namirski et al., [Pol. J. Pharmacol. Pharm. 30, No. 5, pp. 707-712, (1978)].

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