Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-28
1990-06-19
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514343, 514255, 514318, 5142278, 5142372, 546321, 546194, 546281, 544131, 544 584, 544365, C07D21186, A61K 31455
Patent
active
049354337
ABSTRACT:
Compounds of formula I wherein R.sub.1 is an alkoxy carbonyl, aminocarbonyl, acetyl, benzyl, cyano or nitro group; R.sub.2 is as optionally substituted phenyl, aryl, hetaryl residue; R.sub.3 is an alkoxy-carbonyl group, X is an oxygen or sulphur atom, R.sub.4 is hydrogen, an optionally substituted alkyl, cycloalkyl, alkenyl group, Y is a single bond oxygen, sulphur or substituted nitrogen atom.
Compounds of formula I are prepared by acylation from a 2-mercaptomethyl-1,4-dihydropyridine and are useful in therapy.
REFERENCES:
patent: 4284634 (1981-08-01), Sato
patent: 4404378 (1983-09-01), Miyano et al.
patent: 4492703 (1985-01-01), Goldmann et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4642310 (1987-02-01), Goldmann et al.
Merk Index 9th edition, pp. 7853-7854.
Frigerio Marco
Gandolfi Carmelo A.
Riva Carlo
Tofanetti Odoardo
Tognella Sergio
Boehringer Mannheim Italia S.p.A.
Fan Jane T.
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