2-Acylimidazole compounds, their synthesis and use as medicinal

Details 2-Acylimidazole compounds, their synthesis and use as medicinal 2-Acylimidazole compounds, their synthesis and use as medicinal

1983-03-10

1986-01-28

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548343, C07D23364, A61K 31415

Patent

active

045671940

ABSTRACT:
The 2-acylimidazole compounds have an alkyl or aryl substitution at the 2-position and an alkyl, hydroxyalkyl, polyhydroxyalkyl or aryl substitution at the 4-position. They exhibit an ability to decrease in vivo leucocyte populations and are consequently useful as immunosuppressive medicinal agents for prevention of transplanted tissue rejection, treatment of leukemia and treatment of cell-mediated autoimmune disease.

REFERENCES:
patent: 3772315 (1973-11-01), Regel et al.
patent: 4124766 (1978-11-01), Paul et al.

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