2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyraz

Details 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyraz 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyraz

1990-12-21

1992-05-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544101, C07D49804, A61K 31535

Patent

active

051168375

ABSTRACT:
The invention relates to novel compounds, 2,9-dihydro(6 or 7)-3-oxo-2,3,4,5-tetrahydropyridazinyl)pyrazolo[4,3-b]benzoxazines. The claimed compounds are inhibitors of phosphodiesterase fraction III and have potent positive inotropic activity. These compounds are useful as cardiotonics or platelet aggregation inhibitors.
This invention also pertains to compositions comprising an effective amount of the compounds, to methods for preparing the claimed compounds and to methods for treating a mammal with the compounds.

REFERENCES:
patent: 4552874 (1985-11-01), Mardin et al.
patent: 4721784 (1988-01-01), Combs
patent: 4766118 (1988-08-01), Combs
patent: 4923869 (1990-05-01), Prucher et al.
patent: 5011839 (1991-04-01), Tanikawa et al.

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