Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-06-09
1981-12-15
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
42424851, 42424854, 424250, 424256, 424263, 424267, 544 586, 544126, 544361, 546 89, A61K 3154, A61K 3144, C07D491052
Patent
active
043059384
ABSTRACT:
The present invention provides 2,8-disubstituted-10-hydroxy-5,5-dimethyl-tetrahydro-and hexahydro-5H-[1]-benzopyrano[4,3-c]pyridines represented by Formulae I-III: ##STR1## wherein: R is selected from the group consisting of C.sub.4 -C.sub.20 straight or branched chain alkyl, C.sub.8 14 C.sub.20 straight or branched chain arylalkyl; n is an integer from 1-4 inclusive; and X is OH, NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 being the same or different members of the group consisting of hydrogen and loweralkyl, and ##STR2## wherein Y is CH.sub.2, S, O or NR.sub.1 ; and the pharmaceutically acceptable salts thereof. The compounds are useful as antihypertensive agents.
REFERENCES:
patent: Re29196 (1977-04-01), Winn
patent: 3429889 (1969-02-01), Shulgin
patent: 3576798 (1971-04-01), Pars et al.
patent: 3991194 (1976-11-01), Harris et al.
patent: 4111942 (1978-09-01), Lee et al.
Abbott Laboratories
Jiles Henry R.
Niblack Robert L.
Ramsuer R. W.
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