2,6 Disubstituted penems and intermediates therefor

Details 2,6 Disubstituted penems and intermediates therefor 2,6 Disubstituted penems and intermediates therefor

1981-04-13

1983-09-27

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20508, C07D49904

Patent

active

044068344

ABSTRACT:
This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

REFERENCES:
patent: 4070477 (1978-01-01), Ernest
patent: 4155912 (1979-05-01), Menard
patent: 4192801 (1980-03-01), Ueda
patent: 4272437 (1981-06-01), Menard
Woodward et al., Acta Chem. Suecica 14 (supl.) 23 (197).
Clarke, Ed., "Annual Reports in Medranol Chemistry, vol. 13", 1978, pp. 239-248.
Bristol Myers, Chem. Abs. 94, 30747g (1980).

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