2,6-Disubstituted penem compounds

Details 2,6-Disubstituted penem compounds 2,6-Disubstituted penem compounds

1979-09-21

1981-08-04

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424270, 260239A, C07D49900

Patent

active

042821509

ABSTRACT:
This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4168314 (1979-09-01), Christensen et al.
patent: 4182711 (1970-01-01), Veda
Eglington, JCS, Chem. Comm. (1977) p. 720.
Brown et al., J.C.S., Chem. Comm. (1977) pp. 359-360.
Acta Pharmaceutica Suecica, vol. 14 (suppl.), pp. 23-25 (1977).
Annual Reports in Medicinal Chemistry, 13, 239-248 (1978).

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