2,6-disubstituted derivatives of 3-nitropyrazines useful as adju

Details 2,6-disubstituted derivatives of 3-nitropyrazines useful as adju 2,6-disubstituted derivatives of 3-nitropyrazines useful as adju

1984-09-04

1987-11-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544427, 544408, 544409, 514255, A61K 31495, C07D24116, C07D24124

Patent

active

047090359

ABSTRACT:
2,6-Disubstituted derivatives of 3-nitropyrazine are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3660397 (1972-05-01), Jones et al.
patent: 4594349 (1986-06-01), Beyer
Hartman, et al., Non-Mutagenic Nitro-Heterocycles . . . ", Mutation Research 117(1983) 272-277.
Taylor, et al., Conversion of a Primary Amino Group into a Nitroso Group . . . ", J. Org. Chem. (1982) 47: 552-555.

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